PT-141 is a powerful peptide hormone developed by Palatin Technologies and licensed to Valeant Pharmaceuticals. It is best known by its trade name Vyleesi. PT-141 works by activating the melanocortin receptors in the brain, which are responsible for regulating sexual arousal and desire in both men and women. This makes PT-141 unique, as most medications for sexual dysfunction target the vascular system. By directly stimulating the brain pathways involved in sexual response, PT-141 can increase libido and sexual desire in patients with otherwise normal sexual function. It has been studied specifically for treating low libido in pre-menopausal women. How does PT-141 work? When administered, PT-141 travels through the bloodstream to the brain. Here, it binds to and activates melanocortin receptors in areas like the hypothalamus that control sexual arousal and appetite. This process leads to increased dopamine and oxytocin release, key neurotransmitters involved in sexual desire and pleasure. PT-141 also inhibits sex hormone binding globulin, leading to higher free testosterone levels. The end result is a powerful increase in sexual desire and arousal in both men and women. PT-141 does not directly impact genital function or sensation. What conditions can PT-141 treat? PT-141 was originally developed as a tanning agent before researchers realized its powerful effects on libido. It is currently FDA approved for treating hypoactive sexual desire disorder (HSDD) in premenopausal women. HSDD is characterized by chronically low libido and sexual desire that causes personal distress. PT-141 can increase desire and arousal in HSDD patients to normal levels. Research also shows PT-141 increases sexual desire and activity in both men and women in general. It may also help men with erectile dysfunction by improving arousal and motivation for sex. How is PT-141 administered? PT-141 comes as a nasal spray under the brand name Vyleesi. The recommended dosage is 1.8 mg administered about 45 minutes before anticipated sexual activity. It is not intended for continuous daily use. Side effects are mild and may include nausea, headache, and flushing. PT-141 should not be used in those with cardiovascular disease or uncontrolled high blood pressure. As a peptide, PT-141 must be injected if used in compounded formulations. Dosing ranges from 500-2500 mcg injected under the skin. In summary, PT-141 represents an exciting advance in targeting the brain pathways involved in sexual desire and arousal. While more research is needed, it shows promise as a treatment for low libido disorders in both men and women. At Vitality Health Center, we offer PT-141 as part of comprehensive hormone therapy programs tailored to your unique needs. Contact us today to schedule a consultation with one of our hormone therapy specialists to see if PT-141 is right for you. We provide personalized care using the latest advancements in sexual health and vitality.